In 2019 - 2020 ITA COSUF has developed a vision based on discussions, both in public and internal workshops in order to carefully consider the latest and future developments of modern means of transportation from the underground infrastructure perspective. The vision development was backed up with a cooperation between ITA COSUF and PIARC, formally governed by a Memorandum of Understanding between the two organisations that was signed in 2005. ITA COSUF kindly asks the EC Directorates General in charge of the European Union Framework Programme for Research and Innovation 2021 – 2027 (Horizon Europe) to consider ITA COSUF’s view for more detailed topics to be developed in the coming Work Programmes. This document contains ITA COSUF’s vision on New Operational Road Tunnel Safety Issues in a Low Carbon Economy and Smart Mobility Environment. It was prepared by Ben van den Horn, Roland Leucker, Eric Premat, Götz Vollmann and Max Wietek and approved by the Steering Board.